The American Society for Pharmacology and Experimental Therapeutics has revised the Instructions to Authors for Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, and Molecular Pharmacology These revisions relate to knowledge evaluation (together with statistical evaluation) and reporting however don’t inform investigators the way to design and carry out their experiments.
Their general focus is on higher granularity in the outline of what has been carried out and discovered. Key suggestions embrace the necessity to differentiate between preplanned, hypothesis-testing, and exploratory experiments or research; explanations of whether or not key parts of research design, similar to pattern measurement and alternative of particular statistical assessments, had been specified earlier than any knowledge have been obtained or tailored thereafter; and explanations of whether or not any outliers (knowledge factors or total experiments) have been eradicated and when the foundations for doing so had been outlined.
Variability must be described by S.D. or interquartile vary, and precision must be described by confidence intervals; S.E. shouldn’t be used. P values must be used sparingly; in most circumstances, reporting variations or ratios (impact sizes) with their confidence intervals will likely be most well-liked. Depiction of information in figures ought to present as a lot granularity as doable, e.g., by changing bar graphs with scatter plots wherever possible and violin or box-and-whisker plots when not. This editorial explains the revisions and the underlying scientific rationale. We consider that these revised pointers will result in a much less biased and extra clear reporting of analysis findings.
New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology.
The American Society for Pharmacology and Experimental Therapeutics has revised the Instructions to Authors for Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, and Molecular Pharmacology These revisions relate to knowledge evaluation (together with statistical evaluation) and reporting however don’t inform investigators the way to design and carry out their experiments.
Their general focus is on higher granularity in the outline of what has been carried out and discovered. Key suggestions embrace the necessity to differentiate between preplanned, hypothesis-testing, and exploratory experiments or research; explanations of whether or not key parts of research design, similar to pattern measurement and alternative of particular statistical assessments, had been specified earlier than any knowledge have been obtained or tailored thereafter; and explanations of whether or not any outliers (knowledge factors or total experiments) have been eradicated and when the foundations for doing so had been outlined.
Variability must be described by S.D. or interquartile vary, and precision must be described by confidence intervals; S.E. shouldn’t be used. P values must be used sparingly; in most circumstances, reporting variations or ratios (impact sizes) with their confidence intervals will likely be most well-liked. Depiction of information in figures ought to present as a lot granularity as doable, e.g., by changing bar graphs with scatter plots wherever possible and violin or box-and-whisker plots when not. This editorial explains the revisions and the underlying scientific rationale. We consider that these revised pointers will result in a much less biased and extra clear reporting of analysis findings.
Extracting physiological data in experimental biology by way of Eulerian video magnification.
Videographic materials of animals can comprise inapparent indicators, similar to shade adjustments or movement that maintain details about physiological features, similar to coronary heart and respiration charge, pulse wave velocity, and vocalization. Eulerian video magnification permits the enhancement of such indicators to allow their detection.
The function of this research is to display how indicators related to experimental physiology will be extracted from non-contact videographic materials of animals.We utilized Eulerian video magnification to detect physiological indicators in a variety of experimental fashions and in captive and free ranging wildlife. Neotenic Mexican axolotls have been studied to display the extraction of coronary heart charge sign of non-embryonic animals from devoted videographic materials.
Heart charge might be acquired each in single and a number of animal setups of leucistic and usually coloured animals underneath totally different physiological situations (resting, exercised, or anesthetized) utilizing a variety of video qualities. Pulse wave velocity may be measured in the low blood strain system of the axolotl in addition to in the high-pressure system of the human being. Heart charge extraction was additionally doable from movies of acutely aware, unconstrained zebrafish and from non-dedicated videographic materials of sand lizard and giraffe.
This approach additionally allowed for coronary heart charge detection in embryonic chickens in ovo via the eggshell and in embryonic mice in utero and might be used as a gating sign to accumulate two-phase volumetric micro-CT knowledge of the beating embryonic hen coronary heart. Additionally, Eulerian video magnification was used to display how vocalization-induced vibrations will be detected in infrasound-producing Asian elephants.
 Cyclin D1 Antibody |
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| 39315-100ul | SAB | 100ul | EUR 390 |
 Cyclin D1 antibody |
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| 10R-2363 | Fitzgerald | 50 ug | EUR 313 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-2414 | Fitzgerald | 5 mL | EUR 194 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-10331 | Fitzgerald | 100 ug | EUR 435 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-7849 | Fitzgerald | 100 ug | EUR 305 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-8605 | Fitzgerald | 100 ul | EUR 393 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 antibody |
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| 10R-C148a | Fitzgerald | 100 ug | EUR 457 |
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Description: Mouse monoclonal Cyclin D1 antibody |
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Cyclin D1 Antibody |
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| 48497-100ul | SAB | 100ul | EUR 333 |
Cyclin D1 Antibody |
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| 48497-50ul | SAB | 50ul | EUR 239 |
Cyclin D1 Antibody |
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| 48619-100ul | SAB | 100ul | EUR 333 |
Cyclin D1 Antibody |
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| 48619-50ul | SAB | 50ul | EUR 239 |
Cyclin D1 Antibody |
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| DF6386 | Affbiotech | 200ul | EUR 304 |
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Description: Cyclin D1 Antibody detects endogenous levels of total Cyclin D1. |
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Cyclin D1 antibody |
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| 70R-33524 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal Cyclin D1 antibody |
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 Cyclin D1 Antibody |
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| AF0931 | Affbiotech | 200ul | EUR 304 |
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Description: Cyclin D1 Antibody detects endogenous levels of total Cyclin D1. |
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Cyclin D1 Antibody |
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| AF6234 | Affbiotech | 200ul | EUR 304 |
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Description: Cyclin D1 Antibody detects endogenous levels of total Cyclin D1. |
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Cyclin D1 Antibody |
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| ABF6234 | Lifescience Market | 100 ug | EUR 438 |
Cyclin D1 Antibody |
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| ABD6386 | Lifescience Market | 100 ug | EUR 438 |
Cyclin D1 Antibody |
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| ABF0931 | Lifescience Market | 100 ug | EUR 438 |
 Cyclin-D1/ Rat Cyclin- D1 ELISA Kit |
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| ELA-E0585r | Lifescience Market | 96 Tests | EUR 886 |
) Cyclin D1 antibody (Thr286) |
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| 70R-30874 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal Cyclin D1 antibody (Thr286) |
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 Cyclin D1 Polyclonal Antibody |
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| 40803-100ul | SAB | 100ul | EUR 252 |
Cyclin D1 Polyclonal Antibody |
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| 40803-50ul | SAB | 50ul | EUR 187 |
 Antibody) Cyclin D1 (pS90) Antibody |
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| abx010300-100ug | Abbexa | 100 ug | EUR 439 |
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 Antibody) Cyclin D1 (CCND1) Antibody |
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| abx025054-400ul | Abbexa | 400 ul | EUR 523 |
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Cyclin D1 (CCND1) Antibody |
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| abx025054-80l | Abbexa | 80 µl | EUR 286 |
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Cyclin D1 (CCND1) Antibody |
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| abx019062-100ug | Abbexa | 100 ug | EUR 342 |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx214178 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx214742 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx176052 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100478 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100479 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100480 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100481 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100482 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx100483 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx117083-100ug | Abbexa | 100 ug | EUR 467 |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx123072 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx123414 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx125309 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx125624 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx038356-100ug | Abbexa | 100 ug | EUR 391 |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx133903 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx109797 | Abbexa |
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 Antibody) Cyclin D1 (pT286) Antibody |
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| 20-abx121863 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx121864 | Abbexa |
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Cyclin D1 (pS90) Antibody |
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| abx149011-100ug | Abbexa | 100 ug | EUR 439 |
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 Antibody) Cyclin D1 (pT288) Antibody |
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| abx149012-100ug | Abbexa | 100 ug | EUR 439 |
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Cyclin D1 (CCND1) Antibody |
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| abx139064-01mg | Abbexa | 0.1 mg | EUR 425 |
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Cyclin D1 (CCND1) Antibody |
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| abx140376-01mg | Abbexa | 0.1 mg | EUR 356 |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx171973 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx011703-100ul | Abbexa | 100 ul | EUR 411 |
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Cyclin D1 (pT286) Antibody |
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| 20-abx011704 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx031337-400ul | Abbexa | 400 ul | EUR 523 |
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Cyclin D1 (CCND1) Antibody |
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| abx031337-80l | Abbexa | 80 µl | EUR 286 |
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Cyclin D1 (CCND1) Antibody |
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| abx034749-400ul | Abbexa | 400 ul | EUR 523 |
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Cyclin D1 (CCND1) Antibody |
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| abx034749-80l | Abbexa | 80 µl | EUR 286 |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx242422 | Abbexa |
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Cyclin D1 Polyclonal Antibody |
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| EA245-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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Cyclin D1 Polyclonal Antibody |
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| EA245-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
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 Cyclin D1 Conjugated Antibody |
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| C48619 | SAB | 100ul | EUR 397 |
Cyclin D1 Conjugated Antibody |
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| C47994 | SAB | 100ul | EUR 397 |
Cyclin D1 (CCND1) Antibody |
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| 20-abx330261 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx327057 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx328717 | Abbexa |
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Cyclin D1 (CCND1) Antibody |
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| abx448573-100ug | Abbexa | 100 ug | EUR 523 |
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 Antibody) cyclin D1 (CCND1) Antibody |
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| abx432565-200ul | Abbexa | 200 ul | EUR 384 |
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) Cyclin D1 antibody (Biotin) |
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| abx445236-100ug | Abbexa | 100 ug | EUR 578 |
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) Cyclin D1 antibody (FITC) |
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| abx445237-100ug | Abbexa | 100 ug | EUR 565 |
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) Cyclin D1 antibody (HRP) |
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| abx445238-100ug | Abbexa | 100 ug | EUR 565 |
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Cyclin D1 (CCND1) Antibody |
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| abx224352-100ug | Abbexa | 100 ug | EUR 411 |
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Cyclin D1 (CCND1) Antibody |
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| abx224460-100ug | Abbexa | 100 ug | EUR 411 |
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Cyclin D1 (CCND1) Antibody |
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| abx232124-100ug | Abbexa | 100 ug | EUR 481 |
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Cyclin D1 Polyclonal Antibody |
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| ABP51082-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286 |
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Cyclin D1 Polyclonal Antibody |
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| ABP51082-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286 |
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Cyclin D1 Polyclonal Antibody |
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| ABP51082-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286 |
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Cyclin D1 Polyclonal Antibody |
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| ABP57275-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Mouse, Rat. This Cyclin D1 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Cyclin D1 Polyclonal Antibody |
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| ABP57275-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Mouse, Rat. This Cyclin D1 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Cyclin D1 Polyclonal Antibody |
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| ABP57275-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Mouse, Rat. This Cyclin D1 antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Cyclin D1 (CCND1) Antibody |
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| 20-abx001183 | Abbexa |
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Cyclin D1 Polyclonal Antibody |
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| ABP56018-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of S90 |
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Cyclin D1 Polyclonal Antibody |
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| ABP56018-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of S90 |
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Cyclin D1 Polyclonal Antibody |
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| ABP56018-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of Cyclin D1 from Human, Mouse, Rat. This Cyclin D1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of S90 |
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Cyclin D1 Polyclonal Antibody |
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| ES8274-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC |
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Cyclin D1 Polyclonal Antibody |
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| ES8274-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC |
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Cyclin D1 Polyclonal Antibody |
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| ES2081-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Cyclin D1 Polyclonal Antibody |
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| ES2081-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Cyclin D1 Polyclonal Antibody |
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| ES7017-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Cyclin D1 Polyclonal Antibody |
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| ES7017-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Cyclin D1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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 anti- Cyclin D1 antibody |
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| FNab02124 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against Cyclin D1 |
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 Anti-Cyclin D1 antibody |
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| STJ92537 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Cyclin D1. |
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Anti-Cyclin D1 antibody |
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| STJ92538 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Cyclin D1 is a protein encoded by the CCND1 gene which is approximately 33,7 kDa. Cyclin D1 is localised to the nucleus and cytoplasm. It is involved in CDK-mediated phosphorylation and removal of Cdc6, cyclins and cell cycle regulation. This protein falls under the highly conserved cyclin family. It is a regulatory component of the cyclin D1-CDK4 complex that phosphorylates and inhibits members of the retinoblastoma protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D1 is expressed in the nervous system, liver, skin, intestine and lung. Mutations in the CCND1 gene may result in multiple myeloma. STJ92538 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cyclin D1 protein. |
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 Anti-cyclin D1 antibody |
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| STJ73356 | St John's Laboratory | 100 µg | EUR 359 |
Anti-Cyclin D1 antibody |
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| STJ180082 | St John's Laboratory | 0.1 ml | EUR 246 |
Anti-Cyclin D1 antibody |
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| STJ180381 | St John's Laboratory | 0.1 ml | EUR 231 |
Anti-Cyclin D1 antibody |
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| STJ97480 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Cyclin D1. |
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Anti-Cyclin D1 antibody |
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| STJ97978 | St John's Laboratory | 100 µl | EUR 234 |
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Description: Mouse monoclonal to Cyclin D1. |
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Eulerian video magnification gives a method to extract inapparent temporal indicators from videographic materials of animals. This will be utilized in experimental and comparative physiology the place contact-based recordings (e.g., coronary heart charge) can’t be acquired.