Experimental Biology

Life Sience Research

Training biochemistry students in experimental developmental biology: Induction of cardia bifida formation in the chick embryo

Posted on by Marcus
Training biochemistry students in experimental developmental biology: Induction of cardia bifida formation in the chick embryo
A excessive selection of experimental mannequin organisms have been used in developmental biology sensible lectures. The work with creating embryos is essential to make students conscious of the a number of organic phenomena underlying regular animal embryogenesis and morphogenesis and symbolize a novel experimental platform to research the affect of molecular signaling in the regulation of all these processes.
In specific, Biochemistry undergraduate students take pleasure in each sensible and theoretical lectures on the molecular mechanisms of embryonic improvement, as that permits them for the integration of essential molecular ideas (e.g. signaling and sign transduction mechanisms; molecular patterning of improvement) into the dynamic and progressive context of animal embryonic ontogenesis.
Accordingly, you will need to rigorously design sensible laboratory lectures in developmental biology, as these are a novel pedagogical instruments fostering the pursuits of the students in this topic. This examine describes the design, implementation, and analysis of a two-session laboratory sensible exercise carried out by Biochemistry undergraduate students at University of Málaga (Spain).
In this sensible exercise, which takes benefit of the distinctive traits of the chick embryo, students find out how the vertebrate coronary heart types from the fusion of two bilateral-symmetric cardiac progenitor swimming pools below the steerage of the underlying endoderm. This low-cost and simple sensible laboratory exercise supplies related visible data on how experimental manipulations can severely affect anatomical type throughout organ improvement, in addition to a superb experimental setting to check molecular regulation of morphogenesis in an ex vivo (ex ovo) context.

Analysis of a COVID-19 Clinical Trial to Emphasize Experimental Design and Quantitative Reasoning in an Introductory Biology Course

Increasing scholar publicity to major literature in early biology coursework can improve scientific literacy and quantitative reasoning expertise. The efficacy of major literature dialogue is closely impacted by article choice, as scholar engagement is perfect with materials that’s topical and has clear relevance to actual world points. During the COVID-19 pandemic, the prevalence of COVID-19-related scientific analysis in the mainstream media makes it a great subject for present dialogue in entry-level biology programs.
Here, we current an exercise developed to facilitate a distant, synchronous dialogue of an open entry scientific trial publication on the experimental drug remdesivir in the remedy of COVID-19 (Beigel et al., 2020, N Engl J Med https://doi.org/10.1056/nejmoa2007764). The exercise, which is amenable to adaptation for different analysis articles, emphasizes ideas in experimental design, statistical evaluation, graphical interpretation, and the construction, content material, and group of typical sections of a major analysis article. Importantly, the exercise highlights the utility of the classroom response instrument Pear Deck, a Google Slides add-on, for creating participating literature discussions that may be readily tailored to all kinds of instructing modalities.

Experimental techniques biology approaches reveal interplay mechanisms in mannequin multispecies communities

Interactions between microorganisms in multispecies communities are thought to have substantial penalties for the neighborhood. Identifying the molecules and genetic pathways that contribute to such interaction is thus essential to know in addition to modulate neighborhood dynamics. Here I concentrate on latest research that make the most of experimental techniques biology strategies to check these phenomena in simplified mannequin microbial communities.
These unbiased biochemical and genomic approaches have recognized novel interactions and described the underlying genetic and molecular mechanisms. I talk about the insights offered by these research, describe progressive methods used to research much less tractable organisms and environments, and spotlight the utility of integrating these and extra focused strategies to comprehensively characterize interactions between species in microbial communities.
Training biochemistry students in experimental developmental biology: Induction of cardia bifida formation in the chick embryo

Experimental Methodologies to Visualize Early Cell Biology in Zebrafish Embryos

For organisms to perform usually, organic molecules should work at the appropriate time in the proper cells and inside the proper intracellular compartments of cells. Biological analysis depends closely on discovering the mobile areas at which such molecular interactions happen.
A mainstay method in this course of of discovery is the visualization of areas of proteins in cells and tissues, often called immunocytochemistry and immunohistochemistry, respectively. If carried out appropriately, these strategies can present detailed data concerning the endogenous areas of proteins and their ectopic areas or absence in mutants and in illness states.

Melanoma Single-Cell Biology in Experimental and Clinical Settings

Cellular heterogeneity is considered a significant factor for remedy response and resistance in a range of malignant tumors, together with malignant melanoma. More latest developments of single-cell sequencing know-how offered deeper insights into this phenomenon. Single-cell knowledge had been used to determine prognostic subtypes of melanoma tumors, with a particular emphasis on immune cells and fibroblasts in the tumor microenvironment.
Moreover, remedy resistance to checkpoint inhibitor remedy has been proven to be related to a set of differentially expressed immune cell signatures unraveling new targetable intracellular signaling pathways. Characterization of T cell states below checkpoint inhibitor remedy confirmed that exhausted CD8+ T cell sorts in melanoma lesions nonetheless have a excessive proliferative index.
Other research recognized remedy resistance mechanisms to focused remedy towards the mutated BRAF serine/threonine protein kinase together with repression of the melanoma differentiation gene microphthalmia-associated transcription issue (MITF) and induction of AXL receptor tyrosine kinase. Interestingly, remedy resistance mechanisms not solely included choice processes of pre-existing subclones but additionally transition between totally different states of gene expression.

ELISA kit for General Creatinine
EK4382 96 tests
EUR 602.4
Description: Enzyme-linked immunosorbent assay kit for quantification of General Creatinine in samples from serum, plasma, tissue homogenates and other biological fluids.

Creatinine ELISA Kit| Mouse Creatinine ELISA Kit
EF013537 96 Tests
EUR 826.8

ELISA kit for Human Creatinine (Cr)
KTE62273-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Creatinine (Cr) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Creatinine (Cr)
KTE62273-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Creatinine (Cr) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Creatinine (Cr)
KTE62273-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Creatinine (Cr) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human Urinary Creatinine(Urinary Creatinine) ELISA Kit
QY-E05390 96T
EUR 433.2

Creatinine [BTG]
DAGA-186G 500ug
EUR 1425.6

Creatinine-HRP
80-1133 500 ul
EUR 159.6
Description: Creatinine Conjugate for use in immunoassays

Creatinine-HRP
DAG-CL005 500 μl
EUR 1248

Creatinine(N) [HRP]
DAG1075 0.5ml
EUR 1014

ELISA kit for Human Urinary creatinine (UCR)
KTE62727-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Urinary creatinine (UCR) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Urinary creatinine (UCR)
KTE62727-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Urinary creatinine (UCR) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Urinary creatinine (UCR)
KTE62727-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Urinary creatinine (UCR) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Creatinine N-HRP
80-1132 500 ul
EUR 970.8
Description: Creatinine N Conjugate for use in immunoassays

Creatinine Assay Kit
abx098422-Hitachi7020R150ml3R250ml1 Hitachi 7020; R1: 50ml×3 R2: 50ml×1
EUR 622.8

Creatinine Assay Kit
abx098422-Hitachi7060R190ml2R260ml1 Hitachi 7060; R1: 90ml×2 R2: 60ml×1
EUR 566.4

Creatinine Assay Kit
abx098422-Toshiba120R140ml3R240ml1 Toshiba 120; R1: 40ml×3 R2: 40ml×1
EUR 679.2

Creatinine Assay Kit
abx098422-Toshiba120R150ml3R250ml1 Toshiba 120; R1: 50ml×3 R2: 50ml×1
EUR 622.8

Creatinine Assay Kit
abx098422-Toshiba40R150ml3R250ml1 Toshiba 40; R1: 50ml×3 R2: 50ml×1
EUR 622.8

Creatinine Assay Kit
55R-1467 100 assays
EUR 765.6
Description: Assay Kit for detection of Creatinine in the research laboratory

Creatinine ELISA Kit
DLR-Crtn-Ge-48T 48T
EUR 562.8
Description: A competitive inhibition quantitative ELISA assay kit for detection of Creatinine in samples from serum, plasma, tissue homogenates or other biological fluids.

Creatinine ELISA Kit
DLR-Crtn-Ge-96T 96T
EUR 729.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of Creatinine in samples from serum, plasma, tissue homogenates or other biological fluids.

Creatinine Assay Kit
Z5030020 500 assays
EUR 636

Creatinine N antibody
20-1373 100 ul
EUR 1054.8
Description: Sheep polyclonal Creatinine N antibody

Creatinine Standard, 1ML
C003-1ML 1ML
EUR 218

Creatinine (Cr) CLIA Kit
abx197924-96tests 96 tests
EUR 990

Creatinine Acid antibody
20-1244 100 ul
EUR 651.6
Description: Sheep polyclonal Creatinine Acid antibody

Creatinine Standard, 100UL
C003-100UL 100UL
EUR 85

Creatinine Solution, 100ML
X116-100ML 100ML
EUR 94

Creatinine Solution, 25ML
X120-25ML 25ML
EUR 144

Creatinine (Cr) ELISA Kit
abx257719-96tests 96 tests
EUR 801.6

Creatinine (Cr) ELISA Kit
abx350661-96tests 96 tests
EUR 801.6

Rat Creatinine ELISA kit
E02C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Creatinine ELISA kit
E02C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Creatinine ELISA kit
E02C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Creatinine ELISA kit
E08C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Creatinine ELISA kit
E08C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Creatinine ELISA kit
E08C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Creatinine ELISA kit
E07C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Creatinine ELISA kit
E07C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Creatinine ELISA kit
E07C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Creatinine (Rat) ELISA Kit
E4370-100 each
EUR 966

2‐AMINO ACETAMIDE HYDROCHLORIDE (GLYCINAMIDE HYDROCHLORIDE)
101003 each Ask for price

Goat Creatinine ELISA kit
E06C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Creatinine ELISA kit
E06C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Creatinine ELISA kit
E06C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Forodesine (hydrochloride)
HY-16209 2500ug
EUR 639.6

Mouse Creatinine ELISA Kit
DEIABL-M4 96T
EUR 752.4
Description: This CD Creatinine ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Mouse Creatinine. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

Human Creatinine ELISA kit
E01C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Creatinine ELISA kit
E01C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Creatinine ELISA kit
E01C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Creatinine ELISA kit
E03C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Creatinine ELISA kit
E03C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Creatinine ELISA kit
E03C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Creatinine (Human) ELISA Kit
E4368-100 each
EUR 907.2

Creatinine (Mouse) ELISA Kit
E4369-100 each
EUR 966

Rabbit Creatinine ELISA kit
E04C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatinine ELISA kit
E04C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatinine ELISA kit
E04C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Creatinine ELISA kit
E09C0629-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Creatinine ELISA kit
E09C0629-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Creatinine ELISA kit
E09C0629-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Creatinine in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Creatinine (Cr) CLIA Kit
abx196865-96tests 96 tests
EUR 990

DOI hydrochloride
B5321-10 10 mg
EUR 205.2

DOI hydrochloride
B5321-5 5 mg
EUR 141.6

DOI hydrochloride
B5321-50 50 mg
EUR 714

DOB hydrochloride
B5344-1 1 mg
EUR 141.6

Q94 hydrochloride
B5705-10 10 mg
EUR 350.4

Q94 hydrochloride
B5705-50 50 mg
EUR 1264.8

GMQ hydrochloride
B5793-10 10 mg
EUR 212.4

GMQ hydrochloride
B5793-50 50 mg
EUR 711.6

AMT hydrochloride
B6480-10 10 mg
EUR 205.2

AMT hydrochloride
B6480-100 100 mg
EUR 1036.8

AMT hydrochloride
B6480-5 5 mg
EUR 141.6

AMT hydrochloride
B6480-50 50 mg
EUR 673.2

BEC (hydrochloride)
HY-19548A 25mg
EUR 570

EDC hydrochloride
GP0849-100G 100 g
EUR 141.6

EDC hydrochloride
GP0849-250G 250 g
EUR 237.6

EDC hydrochloride
GP0849-25G 25 g
EUR 84

EDC hydrochloride
GP0849-5G 5 g
EUR 55.2

SAG (hydrochloride)
HY-12848B 10mg
EUR 321.6

EDC hydrochloride
GP0849-100 100
EUR 87.1

EDC hydrochloride
GP0849-25 25
EUR 39.4

EDC hydrochloride
GP0849-250 250
EUR 166

EDC hydrochloride
GP0849-5 5
EUR 15.9

General Creatinine ELISA Kit
RDR-Crtn-Ge-48Tests 48 Tests
EUR 585.6

General Creatinine ELISA Kit
RDR-Crtn-Ge-96Tests 96 Tests
EUR 811.2

General Creatinine ELISA Kit
RD-Crtn-Ge-48Tests 48 Tests
EUR 560.4

General Creatinine ELISA Kit
RD-Crtn-Ge-96Tests 96 Tests
EUR 775.2

Urinary Creatinine Assay Kit
STA-378 192 assays
EUR 518.4
Description: Cell Biolabs? Creatinine Assay Kit measures creatinine levels in urine. Samples are compared to a known concentration of creatinine standard within a 96-well microtiter plate format. Samples and standards are incubated for 30 minutes with a reaction reagent which changes color from yellow to bright orange upon reacting with creatinine, forming the creatinine-picrate complex. The plate is read with a standard 96-well spectrophotometric microplate reader at 490 nm. Higher OD values correlate with high creatinine concentrations. Sample creatinine concentrations are determined by comparison with the known creatinine standards.

Urinary Creatinine Assay Kit
UCR1 1 Kit
EUR 164.4

General Creatinine ELISA Kit
RD-Crtn-Ge-48T 48T
EUR 401.3
Description: serum, plasma, tissue homogenates and other biological fluids.

General Creatinine ELISA Kit
RD-Crtn-Ge-96T 96T
EUR 573.3
Description: serum, plasma, tissue homogenates and other biological fluids.

General Creatinine ELISA Kit
RDR-Crtn-Ge-48T 48T
EUR 421.4
Description: serum, plasma, tissue homogenates and other biological fluids.

General Creatinine ELISA Kit
RDR-Crtn-Ge-96T 96T
EUR 602
Description: serum, plasma, tissue homogenates and other biological fluids.

Rat Cr(Creatinine) ELISA Kit
ER0864 96T
EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Rattus;Sensitivity: 0.75nmol/ml

Rat Creatinine(Cr)ELISA Kit
GA-E0315RT-48T 48T
EUR 380.4

Rat Creatinine(Cr)ELISA Kit
GA-E0315RT-96T 96T
EUR 595.2

Rat Creatinine(Cr)ELISA Kit
QY-E11337 96T
EUR 433.2

Rat Creatinine,Cr ELISA Kit
YLA0560RA-48T 48T
EUR 465

Rat Creatinine,Cr ELISA Kit
YLA0560RA-96T 96T
EUR 600

AMTB hydrochloride
B2978-25 25 mg
EUR 812.4

AMTB hydrochloride
B2978-5 5 mg
EUR 247.2

MPEP hydrochloride
B1151-10 each
EUR 222

MPEP hydrochloride
B1151-50 each
EUR 705.6

S1RA hydrochloride
B1180-10 10 mg
EUR 1144.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-100 100 mg
EUR 4620
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5 5 mg
EUR 819.6
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5.1 10 mM (in 1mL DMSO)
EUR 895.2
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-50 50 mg
EUR 3316.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

THZ1 Hydrochloride
B4736-10 10 mg
EUR 268.8
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-25 25 mg
EUR 477.6
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5 5 mg
EUR 170.4
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5.1 10 mM (in 1mL DMSO)
EUR 205.2
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

EHNA hydrochloride
2265-25 each
EUR 339.6

EHNA hydrochloride
2265-5 each
EUR 138

TAME Hydrochloride
2050-100 each
EUR 151.2

TAME Hydrochloride
2050-1000 each
EUR 574.8

TAME Hydrochloride
2050-500 each
EUR 405.6

DMCM hydrochloride
B7268-10 10 mg
EUR 385.2

DMCM hydrochloride
B7268-100 100 mg
EUR 2210.4

DMCM hydrochloride
B7268-25 25 mg
EUR 776.4

DMCM hydrochloride
B7268-5 5 mg
EUR 277.2

DMCM hydrochloride
B7268-5.1 10 mM (in 1mL H2O)
EUR 297.6

DMCM hydrochloride
B7268-50 50 mg
EUR 1363.2

TRIS hydrochloride
B7299-500000 500 g
EUR 309.6

AMTB hydrochloride
B7559-10 10 mg
EUR 459.6

AMTB hydrochloride
B7559-50 50 mg
EUR 1746

MPEP Hydrochloride
A3633-10 10 mg
EUR 142.8
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPEP Hydrochloride
A3633-50 50 mg
EUR 379.2
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPTP hydrochloride
A3634-10 10 mg
EUR 162
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MPTP hydrochloride
A3634-50 50 mg
EUR 344.4
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MTEP hydrochloride
A3636-10 10 mg
EUR 205.2
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-5 5 mg
EUR 153.6
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-50 50 mg
EUR 686.4
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

PJ34 hydrochloride
A4159-10 10 mg
EUR 142.8
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5 5 mg
EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-50 50 mg
EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-S Evaluation Sample
EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

TCEP hydrochloride
B6055-10000 10 g
EUR 338.4
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-2000 2 g
EUR 150
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-50000 50 g
EUR 1243.2
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

HEAT hydrochloride
B6339-10 10 mg
EUR 321.6

HEAT hydrochloride
B6339-50 50 mg
EUR 1167.6

THIP hydrochloride
B6460-100 100 mg
EUR 358.8

THIP hydrochloride
B6460-25 25 mg
EUR 174

THIP hydrochloride
B6460-50 50 mg
EUR 243.6

EHNA hydrochloride
B6662-10 10 mg
EUR 145.2

EHNA hydrochloride
B6662-25 25 mg
EUR 262.8

N20C hydrochloride
B6980-10 10 mg
EUR 340.8

N20C hydrochloride
B6980-50 50 mg
EUR 1245.6

TMPH hydrochloride
B7053-10 10 mg
EUR 321.6

TMPH hydrochloride
B7053-50 50 mg
EUR 1167.6

DAPI (hydrochloride)
C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)
C3362-25 25 mg
EUR 240

DAPI (hydrochloride)
C3362-5 5 mg
EUR 111.6

AD57 (hydrochloride)
C3080-1 1 mg
EUR 141.6
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-10 10 mg
EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-5 5 mg
EUR 428.4
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

MMAD hydrochloride
ADC-P-019 unit Ask for price

MMAF Hydrochloride
ADC-P-021 unit Ask for price

THZ1 hydrochloride
9544-25 each
EUR 1227.6

THZ1 hydrochloride
9544-5 each
EUR 366

TRIS hydrochloride
GB4431-100G 100 g
EUR 64.8

TRIS hydrochloride
GB4431-1KG 1 kg
EUR 160.8
Taken collectively, single-cell know-how has offered deeper insights into melanoma biology and has put ahead our understanding of the position of tumor heterogeneity and transcriptional plasticity, which can affect on progressive scientific trial designs and experimental approaches.

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