Experimental Biology

Life Sience Research

Systems Biology and Experimental Model Systems of Cancer

Systems Biology and Experimental Model Systems of Cancer
Over the previous decade, we’ve got witnessed an growing quantity of large-scale research which have supplied multi-omics information by high-throughput sequencing approaches. This has notably helped with figuring out key (epi)genetic alterations in cancers. Importantly, aberrations that result in the activation of signaling networks by way of the disruption of regular mobile homeostasis is seen each in most cancers cells and additionally within the neighboring tumor microenvironment.
Cancer methods biology approaches have enabled the environment friendly integration of experimental information with computational algorithms and the implementation of actionable focused therapies, because the exceptions, for the remedy of most cancers. Comprehensive multi-omics information obtained by way of the sequencing of tumor samples and experimental mannequin methods will probably be necessary in implementing novel most cancers methods biology approaches and growing their efficacy for tailoring novel personalised remedy modalities in most cancers.
In this overview, we talk about rising most cancers methods biology approaches based mostly on multi-omics information derived from bulk and single-cell genomics research along with current experimental mannequin methods that play a essential position in understanding (epi)genetic heterogeneity and remedy resistance in most cancers.

The finest predictions in experimental biology are essential and persuasive

A robust option to consider scientific explanations (hypotheses) is to check the predictions that they make. In this fashion, predictions function an necessary bridge between summary hypotheses and concrete experiments. Experimental biologists, nonetheless, typically obtain little steerage on easy methods to generate high quality predictions. Here, we establish two necessary elements of good predictions – criticality and persuasiveness – which relate to the power of a prediction (and the experiment it implies) to disprove a speculation or to persuade a skeptic that the speculation has benefit.
Using an in depth instance, we reveal how striving for predictions which are each essential and persuasive can pace scientific progress by main us to extra highly effective experiments. Finally, we offer a top quality management guidelines to help college students and researchers as they navigate the hypothetico-deductive methodology from puzzling observations to experimental checks.

Literature-based studying and experimental design mannequin in molecular biology educating for medical college students at Tongji University

In 2018, to assist undergraduate medical college students strengthen their self-learning and scientific analysis expertise, we launched an tutorial mannequin that mixed literature-based studying with experimental design. We examined this mannequin on the molecular biology class at Tongji University. In step one of the mannequin, a subject is chosen, and college students discover, learn, and consider scientific papers in teams and ship shows.
In the second step, they design scientific experiments in teams and talk about their proposed experiments at school, which is to be adopted by additional experimental verification within the lab course. This total exercise was given 20% weightage within the ultimate rating. The mannequin led to raised student-centered educating and self-directed studying in line with quantitative and qualitative evaluation. Students confirmed nice curiosity in literature and analysis.
They loved group work and gained expertise in group and presentation. Apart from a major improve in ultimate rating, evaluation information from college students indicated that they have been glad with this educating mannequin and thought-about it a optimistic expertise. Looking on the optimistic affect of the literature-based studying and experiment design mannequin, we help its continued use for educating molecular biology to undergraduate medical college students.

Increased Scaffolding and Inquiry in an Introductory Biology Lab Enhance Experimental Design Skills and Sense of Scientific Ability

We current a mannequin for the method of redesigning the laboratory curriculum in Introductory Organismal Biology to extend alternatives for significant inquiry and improve pupil recognition of their scientific ability growth. We created scaffolded modules and assignments to permit college students to construct and follow key expertise in experimental design, information evaluation, and scientific writing.
 Systems Biology and Experimental Model Systems of Cancer
Using the Tool for Interrelated Experimental Design, we confirmed considerably larger features in experimental design scores within the redesigned course and a extra constant sample of features throughout a variety of preliminary pupil scores in contrast with the unique format. Students who accomplished the redesigned course rated themselves considerably larger in experimental design, information assortment, and information evaluation expertise in contrast with college students within the authentic format.
Scores on the Laboratory Course Activity Survey have been excessive for each codecs and didn’t considerably differ. However, on written course evaluations, college students within the redesigned course have been extra prone to report that they engaged in “actual science” and their “personal experiments.” They additionally had elevated recognition of their particular analytical and writing ability growth. Our outcomes reveal that intentional, scaffolded instruction utilizing inquiry modules can improve experimental design expertise and sense of scientific potential in an introductory biology course.

The ITGB6 gene: its position in experimental and medical biology

Integrin αvβ6 is a membrane-spanning heterodimeric glycoprotein concerned in wound therapeutic and the pathogenesis of ailments together with fibrosis and most cancers. Therefore, it’s of nice medical curiosity for us to grasp the molecular mechanisms of its biology.

Human Mucin 2 (MUC2) ELISA Kit

DLR-MUC2-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Mucin 2 (MUC2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

DLR-MUC2-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Mucin 2 (MUC2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

DL-MUC2-Hu 96T
EUR 402
Description: tissue homogenates, cell lysates or other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

EK9084 96Т
EUR 799

Human Mucin 2 (MUC2) ELISA Kit

EKL59208-5x96T 5x96T
EUR 3452.78

Human Mucin 2 (MUC2) ELISA Kit

EKL59208-96T 96T
EUR 726.9

Human Mucin 2(MUC2) ELISA Kit

EKC40939-48T 48T
EUR 597.24

Human Mucin 2(MUC2) ELISA Kit

EKC40939-5x96T 5x96T
EUR 4052.7

Human Mucin 2(MUC2) ELISA Kit

EKC40939-96T 96T
EUR 853.2

Human Mucin- 2, MUC2 ELISA KIT

ELI-02458h 96 Tests
EUR 988.8

Human Mucin 2 (MUC2) ELISA Kit

EKN47131-48T 48T
EUR 341.04

Human Mucin 2 (MUC2) ELISA Kit

EKN47131-5x96T 5x96T
EUR 2314.2

Human Mucin 2 (MUC2) ELISA Kit

EKN47131-96T 96T
EUR 487.2

Human Mucin 2 (MUC2) ELISA Kit

AE32275HU-48Tests 48 Tests
EUR 360
Description: Human (Homo sapiens)

Human Mucin 2 (MUC2) ELISA Kit

AE32275HU-96Tests 96 Tests
EUR 680
Description: Human (Homo sapiens)

Human Mucin 2(MUC2) ELISA Kit

CSB-E13122h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Mucin 2 (MUC2) in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Mucin 2(MUC2) ELISA Kit

1-CSB-E13122h
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Mucin 2(MUC2) in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Mucin 2 (MUC2) ELISA Kit

EKU06020-48T 48T
EUR 500.5

Human Mucin 2 (MUC2) ELISA Kit

EKU06020-5x96T 5x96T
EUR 3396.25

Human Mucin 2 (MUC2) ELISA Kit

EKU06020-96T 96T
EUR 715

Human Mucin 2 (MUC2) ELISA Kit

KTE61458-48T 48T
EUR 359
Description: This Human Mucin 2 (MUC2) ELISA Kit employs a two-site sandwich ELISA to quantitate MUC2.

Human Mucin 2 (MUC2) ELISA Kit

KTE61458-96T 96T
EUR 619
Description: This Human Mucin 2 (MUC2) ELISA Kit employs a two-site sandwich ELISA to quantitate MUC2.

Human Mucin 2 (MUC2) ELISA Kit

KTE61458-96T5 96 T×5
EUR 2809
Description: This Human Mucin 2 (MUC2) ELISA Kit employs a two-site sandwich ELISA to quantitate MUC2.

Human Mucin 2 (MUC2) ELISA Kit

KTE61458-96T50 96 T×50
EUR 26209
Description: This Human Mucin 2 (MUC2) ELISA Kit employs a two-site sandwich ELISA to quantitate MUC2.

Human Mucin 2 (MUC2) ELISA Kit

RK09085 96T
EUR 280

Human Mucin 2(MUC2)ELISA Kit

QY-E00290 96T
EUR 472.8

Human Mucin 2 (MUC2) ELISA Kit

RDR-MUC2-Hu-48T 48T
EUR 432.39
Description: tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

RDR-MUC2-Hu-48Tests 48 Tests
EUR 600

Human Mucin 2 (MUC2) ELISA Kit

RDR-MUC2-Hu-96T 96T
EUR 617.72
Description: tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

RDR-MUC2-Hu-96Tests 96 Tests
EUR 830.4

Human Mucin 2 (MUC2) ELISA Kit

RD-MUC2-Hu-48T 48T
EUR 411.8
Description: tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

RD-MUC2-Hu-48Tests 48 Tests
EUR 573.6

Human Mucin 2 (MUC2) ELISA Kit

RD-MUC2-Hu-96T 96T
EUR 588.3
Description: tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

RD-MUC2-Hu-96Tests 96 Tests
EUR 794.4

Human Mucin 2 (MUC2) ELISA Kit

SEA705Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Mucin 2 (MUC2) in tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

SEA705Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Mucin 2 (MUC2) in tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

SEA705Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Mucin 2 (MUC2) in tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

SEA705Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Mucin 2 (MUC2) in tissue homogenates, cell lysates and other biological fluids.

Human Mucin 2 (MUC2) ELISA Kit

4-SEA705Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Mucin 2 (MUC2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Mucin-2 (MUC2) CLIA Kit

20-abx491916
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Mucin-2 (MUC2) ELISA Kit

20-abx152395
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Mucin-2 (MUC2) ELISA Kit

abx055282-96tests 96 tests
EUR 848.4

Human Mucin-2 (MUC2) ELISA Kit

abx250256-96tests 96 tests
EUR 848.4

Human Mucin-2 (MUC2) ELISA Kit

20-abx572107
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Mucin-2,MUC2 ELISA Kit

YLA1987HU-48T 48T Ask for price

Human Mucin-2,MUC2 ELISA Kit

YLA1987HU-96T 96T Ask for price

Human Mucin-2 (MUC2) ELISA Kit

abx055282-100g 100 µg Ask for price

Human Mucin-2 (MUC2) ELISA Kit

abx055282-10g 10 µg
EUR 525

Human Mucin-2 (MUC2) ELISA Kit

abx055282-50g 50 µg Ask for price

Human Mucin-2, MUC2 GENLISA ELISA

KBH3030 1 x 96 wells
EUR 286

Human MUC2/ Mucin-2 ELISA Kit

E1669Hu 1 Kit
EUR 515
Description: SMUC,Intestinal mucin-2

Human MUC2(Mucin-2) ELISA Kit

EH1017 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human MUC2(Mucin-2) ELISA Kit

EKF58952-48T 48T
EUR 396.9

Human MUC2(Mucin-2) ELISA Kit

EKF58952-5x96T 5x96T
EUR 2693.25

Human MUC2(Mucin-2) ELISA Kit

EKF58952-96T 96T
EUR 567

Human MUC2 / Mucin-2 ELISA Kit

E0705h 96T
EUR 736

Recombinant Human Mucin-2 (MUC2), partial

CSB-YP015222HU 5856 mg Ask for price

Recombinant Human Mucin-2(MUC2),partial

AP70569 1mg
EUR 1978

Recombinant Human Mucin-2(MUC2),partial

AP72691 each Ask for price

Recombinant Human Mucin-2 (MUC2), partial

CSB-EP015222HU 1748 mg Ask for price

Recombinant Human Mucin-2 (MUC2), partial

CSB-EP015222HUa0 1749 mg Ask for price

Recombinant Human Mucin-2 (MUC2) ,partial

RPC21702-100ug 100ug
EUR 460.9

Recombinant Human Mucin-2 (MUC2) ,partial

RPC21702-1mg 1mg
EUR 2237.8

Recombinant Human Mucin-2 (MUC2) ,partial

RPC21702-20ug 20ug
EUR 258.7

Recombinant Human Mucin-2 (MUC2) ,partial

RPC26127-100ug 100ug
EUR 460.9

Recombinant Human Mucin-2 (MUC2) ,partial

RPC26127-1mg 1mg
EUR 2237.8

Recombinant Human Mucin-2 (MUC2) ,partial

RPC26127-20ug 20ug
EUR 258.7

Mucin 2 (MUC2) Monoclonal Antibody (Human)

4-MAA705Hu22
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Mucin 2 (MUC2)

Mucin 2 (MUC2) Polyclonal Antibody (Human)

4-PAA705Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Mucin 2 (MUC2)

Human MUC2 -Mucin 2- CLIA Kit

E-CL-H0484-24Tests 24 Tests
EUR 180
Description: Sandwich

Human MUC2 -Mucin 2- CLIA Kit

E-CL-H0484-48Tests 48 Tests
EUR 546
Description: Sandwich

Human MUC2 -Mucin 2- CLIA Kit

E-CL-H0484-96Tests 96 Tests
EUR 682
Description: Sandwich

Human MUC2 -Mucin 2- CLIA Kit

E-CL-H0484-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human MUC2 -Mucin 2- CLIA Kit

E-CL-H0484-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human MUC2 (Mucin 2) ELISA Kit

EKE60427-5x96T 5x96T
EUR 3124.08

Human MUC2 (Mucin 2) ELISA Kit

EKE60427-96T 96T
EUR 657.7

Human MUC2(Mucin 2) ELISA Kit

ELK2010-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MUC2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MUC2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MUC2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MUC2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human MUC2(Mucin 2) ELISA Kit

ELK2010-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MUC2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MUC2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MUC2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MUC2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human MUC2(Mucin 2) ELISA Kit

RE1352H-48wells 48 wells
EUR 125.55

Human MUC2(Mucin 2) ELISA Kit

RE1352H-96wells 96 wells
EUR 179.55

Human Mucin 2 ELISA Kit (MUC2)

RK01895 96 Tests
EUR 625.2

ELISA kit for Human Mucin 2 (MUC2)

KTE61458-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Mucin 2 (MUC2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Native Mucin 2 (MUC2)

4-NPA705Po01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Mucin 2 expressed in: Pig

Native Mucin 2 (MUC2)

RPU51987-100ug 100ug
EUR 219

Native Mucin 2 (MUC2)

RPU51987-1mg 1mg
EUR 624

Native Mucin 2 (MUC2)

RPU51987-50ug 50ug
EUR 96

Mucin 2 (MUC2) Antibody

20-abx100188
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mucin 2 (MUC2) Antibody

20-abx100190
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mucin 2 (MUC2) Antibody

20-abx100191
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mucin 2 (MUC2) Antibody

20-abx100192
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  • 100 ug
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  • 1 mg
  • 200 ug
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Mucin 2 (MUC2) Antibody

20-abx129925
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  • 100 ug
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  • 1 mg
  • 200 ug
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Mucin 2 (MUC2) Antibody

20-abx132407
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mucin 2 (MUC2) Antibody

20-abx173624
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  • 1 mg
  • 200 ug

Mucin 2 (MUC2) Antibody

abx216977-100ug 100 ug
EUR 526.8

Mucin 2 (MUC2) Antibody

20-abx177611
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  • 1 mg
  • 200 ug

Mucin 2 (MUC2) Antibody

20-abx177612
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  • 1 mg
  • 200 ug

Mucin 2 (MUC2) Antibody

20-abx177613
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  • 100 ug
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  • 1 mg
  • 200 ug
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Mucin 2/MUC2, Antibody

GWB-3F513F 1 ml Ask for price

Mucin 2/MUC2, Antibody

GWB-753A84 7 ml Ask for price

Mucin-2 (MUC2) Antibody

20-abx211009
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  • 100 ul
  • 50 ul

Mucin-2 (MUC2) Antibody

20-abx211010
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  • 100 ul
  • 50 ul

Mucin-2 (MUC2) Antibody

20-abx304587
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Mucin-2 (MUC2) Antibody

abx413310-02mg 0.2 mg
EUR 678

Mucin-2 (MUC2) Antibody

abx100188-100l 100 µl
EUR 250

Mucin-2 (MUC2) Antibody

abx100188-1ml 1 ml
EUR 675

Mucin-2 (MUC2) Antibody

abx100188-200l 200 µl
EUR 312.5

Mucin-2 (MUC2) Antibody

abx100190-100l 100 µl
EUR 262.5

Mucin-2 (MUC2) Antibody

abx100190-1ml 1 ml
EUR 687.5

Mucin-2 (MUC2) Antibody

abx100190-200l 200 µl
EUR 325

Mucin-2 (MUC2) Antibody

abx100191-100l 100 µl
EUR 262.5

Mucin-2 (MUC2) Antibody

abx100191-1ml 1 ml
EUR 687.5
As the limiting binding accomplice within the heterodimer, the β6 subunit controls αvβ6 expression and availability. Here we describe our understanding of the ITGB6 gene encoding the β6 subunit, together with its construction, transcriptional and post-transcriptional regulation, the organic results noticed in ITGB6 poor mice and medical circumstances of ITGB6 mutations.

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